Saturday's two-game slate is highlighted by Lionel Messi and Cristiano Ronaldo, but fantasy players are going to need some value plays if they want to roster both superstars.
The final round of group stage matches kick off Monday, With Spain and Portugal still looking to lock up their spots in the round of 16.
It's going to be very tough fitting in attackers from Uruguay and Spain on Wednesday's two-game slate, but Chris Owen has a few value plays who could help out.
Wednesday's slate includes multiple players with massive anytime goal scorer odds, so finding values to pair with players like Cristiano Ronaldo will be key.
Wednesday's slate includes Spain, Uruguay and Portugal, each of whom are overwhelming favorites, which means fantasy players will have to make some very tough choices.
Friday's three-game slate is highlighted by the big Spain v. Portugal match, but RotoWire's Andrew Laird explains why it might be a game to ignore for fantasy purposes.
Uruguay are significant favorites to win Group A, but the bigger story line will be whether Russia can avoid being just the second host nation to not reach the knockout rounds.
Argentina need a result in Ecuador to book their ticket to the World Cup, and they'll be relying heavily on Lionel Messi to get them there.
Mexico is the biggest favorite on Thursday's two-game slate, but the other three teams can still provide plenty of fantasy points.
While Tuesday's two-game slate doesn't have a ton of firepower, Evan Morter breaks down where the fantasy points should fall.
Brazil and Argentina highlight Thursday's four-game CONMEBOL World Cup qualifying slate, but Andrew Laird explains why fantasy players may want to look elsewhere for big fantasy scores.
Neymar has been dominant in Brazil's World Cup qualifiers this year, and he'll now face off against a Bolivia side that is the biggest underdog on Thursday's slate.
With Lionel Messi's status for this week still up in the air, finding the right alternatives will be the key to fantasy success.
Chris Henne is looking to pair Andre-Pierre Gignac and Urreta for Saturday's Liga MX slate, which means finding the right value plays will be even more important.
RotoWire's Chris Henne breaks down his top player picks and strategies for Saturday's Liga MX action, which includes a number of heavy favorites.