Fenerbahce stacks are likely to be plentiful on Friday's showdown slate, as they are heavy favorites at home to Kayserispor.
Chile can clinch the top spot in Group C with just a draw Monday, but Uruguay come in favored to win the clash of titans.
Chile is the biggest favorite on Monday's three-game Copa America/Gold Cup interleague slate, though there aren't expected to be a ton of goals scored.
Argentina need a result in Ecuador to book their ticket to the World Cup, and they'll be relying heavily on Lionel Messi to get them there.
The United States needs a result in Honduras on Tuesday to keep their World Cup hopes alive, and if they are to do it, Christian Pulisic is likely to play a big part.
Brazil have already qualified for the World Cup, but fantasy managers should still be able to rely on Neymar if he gets a start against Ecuador.
Chile and Germany face off in the tournament final, but there could be plenty of fantasy points in the third-place game between Portugal and Mexico.
With two lop-sided matchups on Sunday's slate, Evan Morter breaks down which players should be the most targeted by fantasy managers.
Chile v. Germany is the marquee match on Wednesday's slate, but Evan Morter explains why a few Socceroos shouldn't be ignored.
Neymar has been dominant in Brazil's World Cup qualifiers this year, and he'll now face off against a Bolivia side that is the biggest underdog on Thursday's slate.
With Lionel Messi's status for this week still up in the air, finding the right alternatives will be the key to fantasy success.
The United States already clinched their spot in the semifinal, while six teams will compete for the last three spots over the next two days.
With Argentina, Chile and Colombia, not to mention the United States, in action over the next two days, daily fantasy soccer players will have plenty of upper-tier options to choose from.
With the United States back in action, not to mention the hotly anticipated Argentina v. Chile match, DFS players will have plenty of options to choose from on the Monday-Tuesday slate.
RotoWire's Andrew Laird reviews the weekly Dream Teams for the official fantasy game of the Premier League.
Manchester City's Sergio Aguero leads the goal-expectancy charts this week.